Atypical myopathy in the horse

Abstract

Atypical myopathy (AM) is a frequently fatal pasture myopathy that emerges in Europe. Outbreaks are of an acute and unexpected nature and practitioners and owners should be prepared to handle the critically ill patients of this disease. Different hypotheses concerning the etiology and pathogenesis have been described. In this review, the most important hypotheses are summarized, and treatment plans and preventive measures are suggested. At this moment, maple seeds are thought to be the cause of AM. These seeds contain a toxin, hypoglycin A, which may lead to multiple acyl-CoA dehydrogenase deficiency (MADD). Treatment is often limited to supportive care. Since treatment is often unsuccessful, the main emphasis is currently still on prevention.