3A1_0514_ 3D TEXTILE IMPLANTS FOR BONE REGENERATION FROM SILK GENERATED BY ADDITIVE MANUFACTURING

Abstract

In order to overcome the limited source of autologous bone graft substitutes for filling bone defects, various experimental approaches have been investigated. The combination of silk and ceramic materials in the the form of membranes or sponges has proven to be promising. For this reason, continuous filaments were spun from native silk solution and manufactured into three-dimensional textile implants using an additive manufacturing process. Cell culture analyses showed good biocompatibility of the implants and an induction of bone differentiation, thus demonstrating the high potential for ceramic functionalized textile silk implants.