WHOLE BODY LOCALIZATION OF INTRAVENOUSLY INJECTED LYMPHOBLASTS IN NORMAL RATS
Abstract
Total body distribution of 125IUDR labeled thoracic
duct, mesenteric and peripheral lymph node blasts
was investigated, after i.v. injection into normal
syngeneic rats. Donors of immunoblasts were stimula·
ted with SRBC 1 week before transfer of cells. Lym-
phoblasts, irrespective of the source of origin, accumulated
preferentially in small intestine, lungs,
skin and muscles. There was an evident difference in
the whole body distribution pattern of injected
thoracic duct and lymph node blasts, what points to
the different behaviour of normally circulating immunoblasts.
Only minor differences in distribution
kinetics and sites of accumulation were found between
mesenteric and peripheral blast cells. We put forward
a hypothesis that immunoblasts behave like effector
cells and their preferential localization in small gut,
lungs, and skin may be mediated by antigens ,physiologically"
present on the surface of tissues with
direct contact with the external environment.