INTERSTITIAL HANDLING OF AMINOGLYCOSIDE ANTIBIOTICS AND RADIOGRAPHIC CONTRAST MEDIA IN THE KIDNEY

BM Cramer, V Hegedus, HJ Dieterich

Abstract


Lymphatics of the mammalian kidney originate in

the loose connective tissue around large blood vessels.

This paravasal tissue drains the interstitium. The in-

trarenal lymphatic system consists of interlobular

arcuate, and interlobar vessels according to the

architecture of the arterial system. The interlobar

vessels drain into the hilar lymph vessels. Capsular

lymphatics are connected with the interlobular

lymphatics inconsistantly. The renal medulla is drained

by the venous vasa recta exclusively - there are no

lymphaties in the medulla.

Lymphatic fluid is mainly formed along the small

renal veins as vascular transudate.

After i.v. bolus injection concentrations of amino-

glycosidic antibiotics in renal lymph reflect plasma

values closely. Radiographic contrast media in renal

lymph also showed a close correlation with plasma

values with some indication of tubular secretion.


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