EFFECT OF TRANSIENT INTESTINAL ISCHAEMIA ON THE THORACIC DUCT LYMPH ABSORPTION OF ENDOTOXIN

M Nozickova, V Bartos, J Sedlak

Abstract


One-hour intestinal ischaemia by clamping the
superior mesenteric artery and interrupting the intramural
collaterals was produced in 8 dogs. Thoracic
duct lymph, mesenteric venous blood and arterial
blood were examined before and during intestinal
ischaemia and after revascularization of the small
bowel. Venous blood was the major route of transport
of lactic acid and lactate dehydrogenase from
the ischaemic bowel. Endotoxin activity determined
by the limulus test was found in the lymph before
the induction of intestinal ischaemia in 4 of 6 dogs
while it was absent in arterial blood. After one hour
lasting revascularization endotoxin was present in
the lymph of all dogs and in 3 and 4 dogs in arterial
and mesenteric venous blood respectively. lt was
demonstrated that limulus-positive substances escape
from the intestine both via the lymph and blood.


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