The Effect of Secretin and Pancreozymin on Pancreatico- Duodenal Lympft Flow and Lipase Activity in Normal Dogs and on Thoracic Duct Lymph Flow and Lipase Activity in Rats with Chronic Pancreatitis

Abstract

Bainbridge ( I) was the first to describe that the intravenous injection of secretin
enhanced the rate of secretion of pancreatic juice and thoracic duct lymph flow; he
found a close correlation between pancreatic secretion and the enhancement of lymph
flow. Razin, Feldman and Dreiling (2), also working on dogs, confirmed that secretin
augmented pancreatic secretion and lymph flow from the thoracic duct, and observed
that intravenous pancrcozymin too increased lymph flow, however, neither secretin nor
pancreozymin augmented the activity of amylase in the lymph. Furthermore, lymph flow
was increased by secretin a lso in pancreatectomized dogs while it was not affected after
removal of the small intestine. From these observations it has been concluded that
enhanced lymph flow from the thoracic duel in response to secretin is derived from
the small intestine and not the pancreas.
In healthy human subjects, secretin was found to augment thoracic duct lymph flow
ar..d amylase and lipase activity in the lymph. whereas it failed to affect either lymph
flow or lipase activity in patients with chronic pancreatitis (3). On the other hand,
Bartos, Br=ek, Groh and 1\.eller (-!) obtained no d1ange in thoracic duel lymph flow in
response to secretin either in healthy individuals or in patients with d1ronic pancreatitis
(.5), however, secretin increased amylase activity in the lymph both in healthy subjects
and patients with chronic pancreatitis while having no appreciable cff ect on lipase
activity. Pancrcozymin augmented thoracic duct lymph flow in healthy individuals and,
simila rly to secretin, increased the activity of amylase in the lymph.
Since there is much controversy about the data pertaining to this question it seemed
worth to investigate whether
l. the flow of pancreaticoduodenal lymph and li pase activity in the lymph of the normal
pancreas arc affected alone by secretin or only in combination with pancreozymin ;
2. whether there is a diffe rence in the secretin and pancreozymin-induced changes of
thoracic duct lymph Ilow and lipase activity in chronic pancreatitis as compared
to the normal pancreas.