LYMPHOCYTE LOCOMOTION III. ULTRASTRUCTURAL STUDIES OF THE LYMPHOCYTE TRAFFIC OVER THE POSTCAPILLARY VENULES OF RAT LYMPH NODES

L Rydgren, B Norberg, C v Mecklenburg, CH Hakansson, N Soderstrom

Abstract


The direction of lymphocytes with amoeboid movement configuration (AMC) was evaluated by means of electron microscopy of ultrathin sections of post-capillary high-endothelium venules (HE-venules) from rat lymph nodes. Out of 104 lymphocytes, 68 lymphocytes appeared to be on their way towards the lumen of the HE-venule and 36 lymphocytes appeared to be moving away from the venular lumen at the moment of fixation. This difference, which was statistically significant (p = 0.0024 ), is thought to reflect the relative size of the migration stream of lymphocytes at the moment of fixation.


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