TIME OF EXCHANGE OF 131 I-LABELED ALBUMIN BETWEEN PLASMA AND PERIPHERAL LYMPH IN MAN

A Engeset, M Aas, W Olszewski, J Sokolowski

Abstract


The passage from blood to peripheral lymph of 131 I-labeled
human serum albumin has been studied in 6
male patients (30 - 70 years) with malignancies without
metastases. On the first day the concentration
of radio-labeled albumin in the blood was
kept almost constant by repeated i.v. injections.
Lymph was collected continuously from a cannulated
subcutaneous lymph vessel on the leg.
Two hours after the first i.v. injection of radio-labeled
albumin the lymph contained significant
amounts of radioactivity in all patients. Equilibrium
between radioactivity in blood and lymph was reached
after 26 hrs. This indicates a long "wash out time"
of unlabeled protein in the interstitial tissue from
where lymph has been sampled.


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