NEW APPROACH TO PROTEIN-LOSING GASTROENTEROPATHY

M Kondo, K Hosakawa, M Masuda

Abstract


Fibrinolytic activity in the biopsicd gastrointestinal
mucosa was investigated in patients with proteinlosing
gastroenteropathy, and the increased activity
was observed in patients associated with erosive
gastritis, Menetrier's disease, atrophic gastritis, or
Crohn's disease. However, patients with intestinal
lymphangiectasia showed normal mucosal fibrinolysis.
Antifibrinolytic therapy with tranexan1ic acid revealed
significant therapeutic effect in the group with
increased mucosal fibrinolysis. It is concluded that
tranexamic acid appeared to be successful in blocking
the yicious circle of "membrane disorder", "increased
tissue fibrinolysis", "increased vascular permeability",
and "hypoproteinemia" in protein-losing gastroenteropathy.


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