IMMUNOLOGIC CHARACTERISTICS OF HUMAN PERIPHERAL LYMPH CELL POPULATIONS

B Lukomska, WL Olszewski, A Engeset

Abstract


Cell population in afferent lymph of human leg
were defin ed by surface characteristics and cytotoxic
activity in 7 normal men and 9 patients with
localized cancer. A higher percentage of E-rosette
forming cells was found in lymph (78.5 and 83.0)
than in blood (60.0 and 63.0, p < 0.05 ). The percentage
of lymph EA-RFC were 10.3 and 18.0, of
EAC-RFC 13.1 and 8.0, of surface immunoglobulin
carrying cells 3.0 and 3.1. In blood 20.6 and 18.0
percent of cells formed EA-ro e ttcs, 23.0 and 15.6
EAC-rosettes, 5 and 9.5 contained surface immunoglobulins.
The differences between lymph and blood
EA- and EAC-RFC in norma.ls were tatistically significant
(p < 0.05). In cancer patients only lymphblood
differences for S Ig + were significant (p <
0.05). No significant differences were found between
normals and cancer patient . In both groups, the natural
cytotoxicity against K 562 cell was 6 times
lower in lymph as compared to blood (p < 0.05 ), the
cytotoxicity in those with cancer was higher than in
normals (p < 0.05). The study indicates that B cells
have a limited tendency toward leaving the blood
circulation and migrating through tissues. Moreover
natural killer cells do not seem to belong to the recirculating
pool of lymphocytes.


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