BIOCHEMICAL CHANGES IN THE BODY FLUIDS AFTER ISCHAEMIC TISSUE INJURY

G Szabo, Z Magyar

Abstract


Lymphatic and tissue fluid LDH activity increases
significantly after 2 hr limb ischaemia but LDH
content in tissue fluid is invariably higher than
in lymph. The differences increase further after 4 hr
ischaemia. The change of GOT concentration in the
body fluids is a less sensitive indicator of tissue damage
than the increase of LDH activity. A 2 or 4 hour
ischaemia does not lead to rupture of lysosomes and
to a marked activity increase of the lysosomal enzymes
acid phosphatase and beta glucuronidase in
tissue fluid and lymph. The earliest biochemical signs
of cellular injury can be detected in the interstitial
fluid of the damaged tissue.


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