EXPERIMENTAL STUDY ON LYMPHATIC VASCULAR CHANGES IN THE DEVELOPMENT OF CANCER

N Tanigawa, T Kanazawa, K Satomura, Y Hikasa, M Hashida, S Muranishi, H Sezaki

Abstract


Sudan Black B and Sudan Blue can partly enter the
lymphatics of the small intestine from the lumen
with long chain fatty acids . By use of a fat emulsion
saturated with them small intestinal and mesenteric
lymphatics were clearly delineated . Subserosa! and
mesenteric lymphatics of the small intestine appeared
as blue lines. With this method we studied anatomical
changes of the lymphatic vessels during the development
of cancer.
As experimental tumor VX2 carcinoma was used.
Lymphatic vessels were not be found in cancerous
regions by this lymphangiographic procedure, even
in the early stages of cancer. Lymphatics passing
through the tumorous tissue were completely obstructed
and accompanied with peripheral dilatation.
Compared to the morphological changes of the blood
vessels, which were studied microangiographically.
the lymphatic vessels were more easily affected by
the malignant growth.


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