IOTASUL, A WATER-SOLUBLE (NON-OILY) CONTRAST MEDIUM FOR DIRECT AND INDIRECT LYMPHOGRAPHY RADIOLOGICAL AND MORPHOLOGICAL INVESTIGATIONS IN DOGS
Abstract
Radiological, light microscopic and electron micro scopic findings after direct and indirect lympho graphy with lotasul, a new non-ionic water-soluble (not oily) contrast medium, are reported. The results of the studies in 18 dogs clearly show that the roentgenological demonstration of the lymph system following intralymphatic administ ration of lotasul in the dog is not inferior to that following the use of conventional oily con contrast medi um passes quickly to the lymphatic system and the lymph nodes and is eliminated within 24 hours. The complications and tissue reactions known from oily contrast media are not observed following use of the new water-soluble contrast medium. Furthermore, studies of the fine structures show unequivocally that no morpho· logically detectable changes attributable to the con trast medium occur either in the region of the injec tion or in the lymph vessels, lymph nodes and organs such as kidney, liver, lung, spleen and myocardium. Preliminary studies indicate that the new contrast medium offers the possibility of indirect demonstration of lymph vessel regions and groups of lymph nodes (indirect lymphography) which have largely escaped detection by the previous routine lympho graphic examination.