CANINE RENAL LYMPH FORMATION DURING ACUTE ECF EXPANSION

RD Bell, A Lowsitisukdi

Abstract


Renal lymph flow, composition and pressure were
related to renal function and hemodynamics before
and during acute extracellular fluid (ECF) expansion
(Ringer's solution, 10% of body wt.) in anesthetized
dogs. ECF expansion caused increases in renal lymph
pressure and flow and a decrease in the plasma concentration
and LIP ratio for protein without altering
the transfer rate of protein from blood to lymph
(lymph clearance). In contrast, the LIP ratios for
creatinine and PAH were unchanged following ECF
expansion while the lymph clearances of these substances
increased roughly in proportion to the increase
in lymph flow. These findings are consistent
with two alternative hypotheses : a) renal lymph
merely participates in the generalized increase in
lymph formation that follows nononcotic ECF dilution,
or b) some or all of the obseryed lymph
flow increase was derived directly from an excess
of tubular reabsorbate.


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