LYMPHO-NODAL FIBROSCLEROSIS IN PRIMARY LYMPHEDEMA PART ONE: CONSIDERATIONS ON LYMPHO-NODAL FIBROSCLEROSIS IN PRIMARY LYMPHEDEMA

IO Rada, N Tudose, R Bibescu Roxin

Abstract


Segments of an inferior inguinal ganglion and of an
external iliac (upper inguinal) ganglion were microscopically
examined in 46 cases of bilateral primary
lymphedema and 26 cases of unilateral primary
lymphedema. The examination was performed bilaterally
and comparatively to a set of ganglions unaffected
by lymphedema, during the years 1974- 1978.
In all the lymph nodes originating from the patients
with lymphedema important morphopathological al ·
ternations were noticed, chiefly consisting in fibrosis,
fibrosclerosis, fat loading, hyalinization processes, giganto-
cellular responses, etc., leading even to an as pect
of cirrhosis, lympho-nodal pseudo-cirrhosis.
These alterations were also found on the healthy
side of the patients with unilateral primary lymphedema
at the time of the microscopical examination.
In the same patient clinical edema appeared in the
following years. The degree of the morphopathological
alterations was greater in the side of the greater
edema and more peculiar in the cases of bulkier
edema.


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