ULTRASTRUCTURAL AND ELECTROPHYSIOLOGIC CHANGES OF EXPERIMENTAL ACUTE CARDIAC LYMPHOSTASIS

P Gloviczki, F Solti, L Szlavy, H Jellinek

Abstract


Experimental impairment of cardiac lymph flow in
dogs produced histologic and electrophysiologic
changes in the heart . Interstitial edema, lipid swelling
of myofibrils, dilatation of lymph vessels. and
fibrinoid degeneration of small coronary arteries occurred
in and near the sinus node and the atrioventricular
conduction system . On electrical stimulation
of the heart, significant shortening of the atrial and
ventricular effective refractory periods, increases in
the sinus node recovery time and in the atrioventri·
cular conduction time, and ventricular extrasystoles
and ventricular fibrillation were observed. Many of
these EKG changes are similar to those observed in
sick sinus syndrome in man. An attempt was made
to create dynamic lymphatic insufficiency by rapid
electrical stimulation of the heart. E KG abnormalities
observed in these cases could be prevented by
intravenous injection of calcium dobesilate .


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