EFFECT OF TERBUTALINE ON PERIPHERAL LYMPH FLOW, PROTEIN CONCENTRATION AND TRANSPORT, AND EDEMA FORMATION AFTER THERMAL INJURY IN RABBITS

G Szabo, Z Magyar, E Posch

Abstract


In the rabbit, intraarterial infusion of 5 micrograms/min
of terbutaline within the first two hours after
moderate thermal injury prevents edema and reduces
augmented lymph flow, lymphatic protein transport,
and tissue fluid protein concentration. Terbutaline,
however, fails to prevent edema 4 hours after thermal
injury although the increase of leg volume (24%)
is less than in the untreated, burned control leg
(56%). A higher dose of terbutaline (15 micrograms/min) also
fails to block edema 4 hours after burning and its effect
on leg volume, lymph flow, and lymphatic protein
concentration is similar to that of 5 micrograms/min infusion.
Terbutaline does not alter the extent of tissue
injury after burning as the increase in tissue fluid
lactic dehydrogenase and potassium are similar with
"treated" and "untreated" burns. 


Full Text:

PDF