THERMAL INJURY AND INDUCED THERMOTOLERANCE IN RAT LYMPH NODES

S Levine, A Mandelbrot, H Eidinoff

Abstract


Immersion of the rat's hind limb in water at 45°
or 46°C for one hour caused a severe burn of the extremity,
including the popliteal lymph node. Pretreatment
one day in advance at 45° C for 15 minutes or
43° C for one hour prevented most of the damage to
lymph node and other tissues. The production of
both thermal necrosis and thermotolerance were
direct effects of heat on the lymph node. The
distribution of necrosis in the lymph node (greatest in
the subcapsular region and least in the medulla)
probably relates to thermal gradients and not to the
microstructure of the nodes, except perhaps for
relative resistance of the medulla.


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