EFFECT OF LEUKOTRIENES C4 AND D4 ON PROSTAGLANDIN I2-LIBERATION FROM HUMAN LYMPHATICS

H Sinzinger, J Kaliman, E Mannheimer

Abstract


Whereas prostaglandin 12 (PGI2), a major
metabolite of human lymphatics, does not itself
affect lymphatic contractility significantly, it is
able to counterbalance the contractile response
to thromboxane and leukotrienes. We now
demonstrate that leukotrienes C4 and D4 evoke
a dose-dependent increased production of PGI2
from human lymphatics. It is likely that
leukotrienes either exert a contractile rhythmic
effect on human lymphatics or, alternatively,
evoke increased PGlz-formation which relaxes
human lymphatics. These mechanisms may be
of local importance in regulating lymphatic
"tone" at sites of inflammation as leukotrienes
are liberated from activated white blood cells.


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