THE EFFECTS OF INTRAVENOUS INFUSION OF SOLUTIONS WITH DIFFERENT COLLOID OSMOTIC PRESSURES ON RAT MESENTERIC LYMPH PRESSURE

M Shinozaki, M Morio, H Kikuchi, T Yamanoue, K Fujii, K Kodama

Abstract


The effects of intravenous infusion of solutions
of varied colloid osmotic pressure on
mesenteric lymph pressure were measured by a
glass micropipette. The lymph pressure was 4.0
± 1.6 cm H20 between the second and third
valve of rat mesenteric lymphatic vessels with
diameter of 101 ± 25μm (mean ± SD). Intravenous
infusion of 1 ml/100g body weight
(B.W.) of isotonic saline, 5% glucose solution,
and 20% glucose solution increased the lymph
pressure by 1.6 ± 0.5 cm H20, 1.5 ± 0.3 cm
H20 and 2.0 ± 1.0 cm H20, respectively. Infusion
of 2 ml/100g B.W. of the same solutions
increased the lymph pressure by 3.3 ± 1.3 cm
H20, 3.3 ± 1.6 cm H20 and 3.7 ± 0.8 cm
H20, respectively . Infusion of hydroxyethyl
starch solution, with colloid osmotic pressure of
25 mmHg, minimally altered the lymph
pressure. One ml/100g B.W. infusion of low
molecular weight dextran solution, with colloid
osmotic pressure of 162 mmHg, decreased the
lymph pressure by 1.3 ± 0.9 cm H20, and 2
ml/1OOg B.W . infusion of this solution decreased
the lymph pressure by 2.0 ± 1.0 cm H20. The
different effects on lymph pressure derive from
the differences in colloid osmotic pressure of these
solutions in conformity with the Starling
hypothesis.


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