ENHANCED PROSTAGLANDIN I2-FORMATION OF HUMAN LYMPHATICS DURING PULSATILE PERFUSION

H Sinzinger, J Kaliman, E Mannheimer

Abstract


Previous studies demonstrate that prostacyclin
(prostaglandin I2, PGI2) is the main
arachidonic acid product in human lymph
vessels. Pulsatile perfusion increases and prolongs
PGirfarmation as do leukotrienes (LT)
such as LTC4. Thus, physical activity besides
local mechanical and biochemical influences on
lymph pressure and flow also stimulates local
lymphatic PGI2 synthesis, a prime counterbalancing
factor in lymphatic constriction induced
by other eicosanoids.


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