ISOPROSTANE 8-EPI-PROSTAGLANDIN F2a IS A POTENT CONTRACTOR OF HUMAN PERIPHERAL LYMPHATICS

H Sinzinger, A Oguogho, J Kaliman

Abstract


Isoprostanes are products of free radical-catalyzed peroxidation and 8-epiprostaglandin (PG) F2 is the most important vasomodulator of this group of compounds. Inhuman lower leg lymphatics isolated from 5 different patients without a smoking history orhyperlipidemia, 8-epi-PGF2 stimulated in vitro contraction more strongly than thethromboxane receptor agonist U46619. Other isoprostanes (8-epi-PGE1, 8-epi-PGE2) hadonly limited lymphatic contractile potency. These data suggest a potentially relevant role for8-epi-PGF2 in facilitating lymph transport especially in conditions of inflammation.

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