SYNCYTIAL VARIANT OF NODULAR SCLEROSING HODGKIN LYMPHOMA

Abstract

We report the case history of a 31-year old woman with a rare morphologic form ofnodular sclerosing Hodgkin disease (NSHD) termed “syncytial variant.” Its histologic featuresmimic metastatic carcinoma, thymoma, melanoma, non-Hodgkin lymphoma and germ-cell tumor.Antigens expressed on Reed-Sternberg cells, the hallmark of Hodgkin disease, and otherneoplastic cells were screened to determine the correct diagnosis. This patient demonstrates theimportance of using specific immunohistochemical techniques to clarify the diagnosis of NSHDof the “syncytial variant” subtype.