EFFECT OF PHOSPHODIESTERASE ill INHIBITOR (OLPRINONE) ON THORACIC DUCT LYMPH FLOW IN ANESTHETIZED SHEEP WITH EXPERIMENTALLY INDUCED HEART FAILURE BY ENDOTHELIN-l

Abstract

We investigated the short-term effects ofa phosphodiesterase III Inhibitor (Olprinone)on hemodynamics and thoracic duct lymphflow in anesthetized open-chest sheep withheart failure induced by endothelin-l(cardiogenic shock). Ultrasound transit-timeflow probes were attached to the thoracicduct, the ascending aorta and the renal artery.Arterial, pulmonary and central venouspressures were monitored. Endothelin-l wasinfused intravenously at a dosage that reducedcardiac output to 50% or more of baseline(n=11). The effects of Olprinone wereexamined (n=5) by intravenous infusion afterendothelin-l administration. Other sheep(n=6) were used as controls. Olprinonesignificantly increased cardiac output that hadbeen decreased by endothelin-l and furtherincreased thoracic duct flow that had beenincreased by endothelin-l. Increased arterialand pulmonary pressures induced byendothelin-l administration were rapidlydecreased by Olprinone. Renal arterial flowand central venous pressure were, however,unchanged by Olprinone. Overall, Olprinoneacutely improved experimental cardiogenicshock (heart failure) induced by endothelin-l,and maintained thoracic duct lymph flow at ahigh level after endothelin-l administration.